„Marseilleviridae“ – Versionsunterschied

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<!-- Für Informationen zum Umgang mit dieser Vorlage siehe bitte [[Wikipedia:Viroboxen]]. -->
{{Italic title}}
{{Infobox Virus
{{Use dmy dates|date=April 2017}}
| Name= Marseilleviridae
{{taxobox
| Bild=
| name = ''Marseilleviridae''
| virus_group = i
| Bild_legende =
| Wiss_Name = Marseillevirus
| ordo =
| Wiss_KurzName =
| familia = '''''Marseilleviridae'''''
| Ordnung = 'Megavirales'
| subdivision_ranks = Genera
| Familie = Marseilleviridae<!--<br /><small>(Philippe Colson et al., 2012)</small> -->
| subdivision =
| Subfamilie =
* ''[[Marseillevirus]]''
| Gattung = Marseillevirus<!--<br /><small>(Mickaël Boyer & Natalya Yutin, 2012)</small> -->
| Spezies =
| Subspezies =
| Genom = dsDNA zirkulär
| Baltimore = 1
| Kapsid = komplex
| Virushülle = vorhanden
| NCBI_Tax =
| NCBI_Ref =
| ICTV =
}}
}}
Die ''Marseilleviridae'' sind eine Virusfamilie, die 2012 erstmals beschrieben wurde.<ref name=pmid23188494>{{cite journal |doi=10.1007/s00705-012-1537-y |pmid=23188494 |title='Marseilleviridae', a new family of giant viruses infecting amoebae |journal=Archives of Virology |volume=158 |issue=4 |pages=915–20 |year=2012 |last1=Colson |first1=Philippe |last2=Pagnier |first2=Isabelle |last3=Yoosuf |first3=Niyaz |last4=Fournous |first4=Ghislain |last5=La Scola |first5=Bernard |last6=Raoult |first6=Didier }}</ref> Das [[Genom]] dieser Viren ist eine doppelsträngige [[DNA]]. Die Wirte sind oft Amöben, aber es gibt Hinweise darauf, dass sie auch beim Menschen gefunden werden.<ref name=pmid25218687>{{cite journal |doi=10.1016/j.micpath.2014.09.005 |pmid=25218687 |title=Looking at protists as a source of pathogenic viruses |journal=Microbial Pathogenesis |volume=77 |pages=131–5 |year=2014 |last1=La Scola |first1=Bernard }}</ref><ref name=pmid23664726>{{cite journal |doi=10.1016/j.jcv.2013.03.018 |pmid=23664726 |title=Evidence of the megavirome in humans |journal=Journal of Clinical Virology |volume=57 |issue=3 |pages=191–200 |year=2013 |last1=Colson |first1=Philippe |last2=Fancello |first2=Laura |last3=Gimenez |first3=Gregory |last4=Armougom |first4=Fabrice |last5=Desnues |first5=Christelle |last6=Fournous |first6=Ghislain |last7=Yoosuf |first7=Niyaz |last8=Million |first8=Matthieu |last9=La Scola |first9=Bernard |last10=Raoult |first10=Didier }}</ref><ref name=pmid23821720>{{cite journal |doi=10.1093/infdis/jit292 |pmid=23821720 |title=Marseillevirus-Like Virus Recovered from Blood Donated by Asymptomatic Humans |journal=The Journal of Infectious Diseases |volume=208 |issue=7 |pages=1042–50 |year=2013 |last1=Popgeorgiev |first1=Nikolay |last2=Boyer |first2=Mickaël |last3=Fancello |first3=Laura |last4=Monteil |first4=Sonia |last5=Robert |first5=Catherine |last6=Rivet |first6=Romain |last7=Nappez |first7=Claude |last8=Azza |first8=Said |last9=Chiaroni |first9=Jacques |last10=Raoult |first10=Didier |last11=Desnues |first11=Christelle }}</ref><ref name=pmid27502174>{{cite journal |doi=10.1016/S1473-3099(16)30051-2 |pmid=27502174 |title=Marseillevirus in lymphoma: A giant in the lymph node |journal=The Lancet Infectious Diseases |volume=16 |issue=10 |pages=e225–e234 |year=2016 |last1=Aherfi |first1=Sarah |last2=Colson |first2=Philippe |last3=Audoly |first3=Gilles |last4=Nappez |first4=Claude |last5=Xerri |first5=Luc |last6=Valensi |first6=Audrey |last7=Million |first7=Matthieu |last8=Lepidi |first8=Hubert |last9=Costello |first9=Regis |last10=Raoult |first10=Didier }}</ref> Die Typusart wurde ursprünglich zum Mimivirus gruppiert [[Mimiviridae]], spätere Studien zeigten jedoch, dass nur eine entfernte Verwandtschaft besteht. Mit Stand 2016 erkannte das Internationale Komitee für Taxonomie von Viren ([[ICTV]]) vier Spezies in dieser Familie an, die auf zwei Gattungen aufgeteilt sind.<ref name=ViralZone>{{cite web |title=Viral Zone |url=http://viralzone.expasy.org/all_by_species/4740.html |publisher=ExPASy |accessdate=25. November 2018 }}</ref><ref name=ICTV>{{cite web |publisher=ICTV |title=Virus Taxonomy: 2016 Release |url=http://ictvonline.org/virusTaxonomy.asp |accessdate=25. November 2018 }}</ref> Die Marseilleviridae gehören zu den [[Nucleocytoplasmic large DNA viruses]] (NCLDV), für die vorgeschlagen wurde, sie als Megavirales in den Rang einer Virusordnung zu erheben.


== Spezies ==
'''''Marseilleviridae''''' is a [[Family (biology)|family]] of [[viruses]] first named in 2012.<ref name=pmid23188494>{{cite journal |doi=10.1007/s00705-012-1537-y |pmid=23188494 |title='Marseilleviridae', a new family of giant viruses infecting amoebae |journal=Archives of Virology |volume=158 |issue=4 |pages=915–20 |year=2012 |last1=Colson |first1=Philippe |last2=Pagnier |first2=Isabelle |last3=Yoosuf |first3=Niyaz |last4=Fournous |first4=Ghislain |last5=La Scola |first5=Bernard |last6=Raoult |first6=Didier }}</ref> The [[genome]]s of these viruses are [[double-stranded DNA]]. [[Amoeba]] are often [[Host (biology)|hosts]], but there is evidence that they are found in [[humans]] as well.<ref name=pmid25218687>{{cite journal |doi=10.1016/j.micpath.2014.09.005 |pmid=25218687 |title=Looking at protists as a source of pathogenic viruses |journal=Microbial Pathogenesis |volume=77 |pages=131–5 |year=2014 |last1=La Scola |first1=Bernard }}</ref><ref name=pmid23664726>{{cite journal |doi=10.1016/j.jcv.2013.03.018 |pmid=23664726 |title=Evidence of the megavirome in humans |journal=Journal of Clinical Virology |volume=57 |issue=3 |pages=191–200 |year=2013 |last1=Colson |first1=Philippe |last2=Fancello |first2=Laura |last3=Gimenez |first3=Gregory |last4=Armougom |first4=Fabrice |last5=Desnues |first5=Christelle |last6=Fournous |first6=Ghislain |last7=Yoosuf |first7=Niyaz |last8=Million |first8=Matthieu |last9=La Scola |first9=Bernard |last10=Raoult |first10=Didier }}</ref><ref name=pmid23821720>{{cite journal |doi=10.1093/infdis/jit292 |pmid=23821720 |title=Marseillevirus-Like Virus Recovered from Blood Donated by Asymptomatic Humans |journal=The Journal of Infectious Diseases |volume=208 |issue=7 |pages=1042–50 |year=2013 |last1=Popgeorgiev |first1=Nikolay |last2=Boyer |first2=Mickaël |last3=Fancello |first3=Laura |last4=Monteil |first4=Sonia |last5=Robert |first5=Catherine |last6=Rivet |first6=Romain |last7=Nappez |first7=Claude |last8=Azza |first8=Said |last9=Chiaroni |first9=Jacques |last10=Raoult |first10=Didier |last11=Desnues |first11=Christelle }}</ref><ref name=pmid27502174>{{cite journal |doi=10.1016/S1473-3099(16)30051-2 |pmid=27502174 |title=Marseillevirus in lymphoma: A giant in the lymph node |journal=The Lancet Infectious Diseases |volume=16 |issue=10 |pages=e225–e234 |year=2016 |last1=Aherfi |first1=Sarah |last2=Colson |first2=Philippe |last3=Audoly |first3=Gilles |last4=Nappez |first4=Claude |last5=Xerri |first5=Luc |last6=Valensi |first6=Audrey |last7=Million |first7=Matthieu |last8=Lepidi |first8=Hubert |last9=Costello |first9=Regis |last10=Raoult |first10=Didier }}</ref> As of 2016, the [[International Committee on Taxonomy of Viruses]] recognize four species in this family, divided among 2 genera.<ref name=ViralZone>{{cite web |title=Viral Zone |url=http://viralzone.expasy.org/all_by_species/4740.html |publisher=ExPASy |accessdate=12 August 2015 }}</ref><ref name=ICTV>{{cite web |publisher=ICTV |title=Virus Taxonomy: 2016 Release |url=http://ictvonline.org/virusTaxonomy.asp |accessdate=6 July 2017 }}</ref> It is a member of the [[nucleocytoplasmic large DNA viruses]] clade.
Das erste bekannte Mitglied dieser Familie wurde als ''Acanthamoeba polyphaga marseillevirus'' ([[Marseillevirus]]) bezeichnet. Ein zweites Mitglied ist ''Acanthamoeba castellanii lausannevirus'' ([[Lausannevirus]]). Ein anderes Mitglied dieser Familie wurde bei Blutspendern isoliert: [[Giant Blood Marseillevirus]] (GBM).<ref name=pmid23821720/> Auch über ein Isolat von Insekten - das [[Insektomimevirus]] - wurde berichtet.<ref name=pmid24157885>{{cite journal |doi=10.1159/000354560 |pmid=24157885 |title=First Isolation of a Marseillevirus in the Diptera Syrphidae ''Eristalis'' tenax |journal=Intervirology |volume=56 |issue=6 |pages=386–94 |year=2013 |last1=Boughalmi |first1=Mondher |last2=Pagnier |first2=Isabelle |last3=Aherfi |first3=Sarah |last4=Colson |first4=Philippe |last5=Raoult |first5=Didier |last6=La Scola |first6=Bernard }}</ref>


Nach aktuellem Stand scheinen die Mitglieder in dieser Familie in mindestens 3 Gruppen zu fallen:
==Taxonomy==
# Marseillevirus und [[Cannes8virus]]
<big>'''Group: dsDNA'''</big>
# Insectomimevirus und [[Tunisvirus]]
{{Collapsible list|title= <big>Order: Unassigned</big>
# Lausannevirus
|1={{Collapsible list| framestyle=border:none; padding:1.0em;|title=Family: Marseilleviridae
|1={{hidden begin|title=<small>Genus: [[Marseillevirus]]</small>}}
*<small>'''''[[Marseillevirus marseillevirus]]'''''</small>
*<small>[[Senegalvirus marseillevirus]]</small>
{{hidden end}}
|2={{hidden begin|title=<small>Genus: Unassigned</small>}}
*<small>[[Lausannevirus]]</small>
*<small>[[Tunisvirus]]</small>
{{hidden end}}
}}
}}
<ref name=ICTV />

===Related Viruses===
[[File:MelVfig2j.jpg|thumb|Images of cryo-frozen ''Marseilleviridae'' particles (left and center) and enlarged diagram of structure near a vertex. Black arrows indicate Large Dense Bodies. White arrows indicate lipid bilayer.]]
Additional species have since been recognized.<ref name=pmid23188494/> The first member of this family recognized has been named ''Acanthamoeba polyphaga marseillevirus''. A second member is ''Acanthamoeba castellanii lausannevirus''. Two additional viruses have been isolated but have yet to be named. Another member of this family has been isolated from blood donors.<ref name=pmid23821720/> An isolate from insects—''Insectomime'' virus—has also been reported.<ref name=pmid24157885>{{cite journal |doi=10.1159/000354560 |pmid=24157885 |title=First Isolation of a Marseillevirus in the Diptera Syrphidae ''Eristalis'' tenax |journal=Intervirology |volume=56 |issue=6 |pages=386–94 |year=2013 |last1=Boughalmi |first1=Mondher |last2=Pagnier |first2=Isabelle |last3=Aherfi |first3=Sarah |last4=Colson |first4=Philippe |last5=Raoult |first5=Didier |last6=La Scola |first6=Bernard }}</ref>

The viruses appear to fall into at least 3 lineages: (1) ''Marseillevirus'' and ''Cannes8virus'' (2) ''Insectomime'' and ''Tunisvirus'' and (3) ''Lausannevirus''. A sixth potential member of this family—''Melbournevirus''—appears to be related to the ''Marseillevirus''/''Cannes8virus'' clade.<ref name=pmid25275139>{{cite journal |doi=10.1128/JVI.02414-14 |pmid=25275139 |pmc=4249118 |title=Genome Analysis of the First Marseilleviridae Representative from Australia Indicates that Most of Its Genes Contribute to Virus Fitness |journal=Journal of Virology |volume=88 |issue=24 |pages=14340–9 |year=2014 |last1=Doutre |first1=G |last2=Philippe |first2=N |last3=Abergel |first3=C |last4=Claverie |first4=J.-M }}</ref>

A seventh virus—Brazilian Marseillevirus—has been reported.<ref name=pmid26978387>{{cite journal |doi=10.3390/v8030076 |pmid=26978387 |pmc=4810266 |title=A Brazilian Marseillevirus is the Founding Member of a Lineage in Family Marseilleviridae |journal=Viruses |volume=8 |issue=3 |pages=76 |year=2016 |last1=Dornas |first1=Fábio |last2=Assis |first2=Felipe |last3=Aherfi |first3=Sarah |last4=Arantes |first4=Thalita |last5=Abrahão |first5=Jônatas |last6=Colson |first6=Philippe |last7=La Scola |first7=Bernard }}</ref> This virus appears to belong to a fourth lineage of virus in this family.

Another virus—Tokyovirus—has also been reported.<ref name=pmid27284144>{{cite journal |doi=10.1128/genomeA.00429-16 |pmid=27284144 |pmc=4901213 |title=Draft Genome Sequence of ''Tokyovirus'', a Member of the Family ''Marseilleviridae'' Isolated from the Arakawa River of Tokyo, Japan |journal=Genome Announcements |volume=4 |issue=3 |pages=e00429–16 |year=2016 |last1=Takemura |first1=Masaharu }}</ref>

Another member of this family is Kurlavirus.<ref name=pmid28685284>{{cite journal |doi=10.1007/s00705-017-3469-z |pmid=28685284 |title=Complete genome sequence of Kurlavirus, a novel member of the family Marseilleviridae isolated in Mumbai, India |journal=Archives of Virology |volume=162 |issue=10 |pages=3243 |year=2017 |last1=Chatterjee |first1=Anirvan |last2=Kondabagil |first2=Kiran }}</ref>

==Structure==
Viruses in Marseilleviridae have icosahedral geometries. The diameter is around 250&nbsp;nm. Genomes are circular, around 372kb in length. The genome has 457 open reading frames.<ref name=ViralZone/>

{| class="wikitable sortable" style="text-align:center"
|-
! Genus !! Structure || Symmetry !! Capsid !! Genomic arrangement !! Genomic segmentation
|-
|Unassigned||Head-Tail||T=16||Non-enveloped||Linear||Monopartite
|-
|Marseillevirus||Icosahedral||||||Circular||
|}

==Life cycle==
Dna templated transcription is the method of transcription. Amoeba serve as the natural host.<ref name=ViralZone/>

{| class="wikitable sortable" style="text-align:center"
|-
! Genus !! Host details !! Tissue tropism !! Entry details !! Release details !! Replication site !! Assembly site !! Transmission
|-
|Marseillevirus||Amoeba||None||Fusion||Lysis||Cytoplasm||Cytoplasm||Diffusion in Water
|}

==Genomics==


A promoter sequence—AAATATTT—has been found associated with 55% of the identified genes in this virus.<ref name=pmid28794030>{{cite journal |doi=10.1128/JVI.01088-17 |pmid=28794030 |pmc=5640848 |title=The Investigation of Promoter Sequences of Marseilleviruses Highlights a Remarkable Abundance of the AAATATTT Motif in Intergenic Regions |journal=Journal of Virology |volume=91 |issue=21 |pages=e01088–17 |year=2017 |last1=Oliveira |first1=Graziele Pereira |last2=Lima |first2=Maurício Teixeira |last3=Arantes |first3=Thalita Souza |last4=Assis |first4=Felipe Lopes |last5=Rodrigues |first5=Rodrigo Araújo Lima |last6=Da Fonseca |first6=Flávio Guimarães |last7=Bonjardim |first7=Cláudio Antônio |last8=Kroon |first8=Erna Geessien |last9=Colson |first9=Philippe |last10=La Scola |first10=Bernard |last11=Abrahão |first11=Jônatas Santos }}</ref> Most of these sequences occur in multiple copies.
Ein sechstes potenzielles Mitglied dieser Familie - [[Melbournevirus]] - scheint mit der Marseillevirus/Cannes8virus-Klade verwandt zu sein.<ref name=pmid25275139>{{cite journal |doi=10.1128/JVI.02414-14 |pmid=25275139 |pmc=4249118 |title=Genome Analysis of the First Marseilleviridae Representative from Australia Indicates that Most of Its Genes Contribute to Virus Fitness |journal=Journal of Virology |volume=88 |issue=24 |pages=14340–9 |year=2014 |last1=Doutre |first1=G |last2=Philippe |first2=N |last3=Abergel |first3=C |last4=Claverie |first4=J.-M }}</ref>


Ein siebtes Virus - das [[Brasilianisches Marseilleviru|Brasilianische Marseillevirus]] - scheint zu einer vierten Viruslinie in dieser Familie zu gehören.<ref name=pmid26978387>{{cite journal |doi=10.3390/v8030076 |pmid=26978387 |pmc=4810266 |title=A Brazilian Marseillevirus is the Founding Member of a Lineage in Family Marseilleviridae |journal=Viruses |volume=8 |issue=3 |pages=76 |year=2016 |last1=Dornas |first1=Fábio |last2=Assis |first2=Felipe |last3=Aherfi |first3=Sarah |last4=Arantes |first4=Thalita |last5=Abrahão |first5=Jônatas |last6=Colson |first6=Philippe |last7=La Scola |first7=Bernard }}</ref>
==History==


Als weitere Mitglieder dieser Familie wurden das [[Tokyovirus]]<ref
One of the first members of this family was described in 2009.<ref name=pmid20007369>{{cite journal |doi=10.1073/pnas.0911354106 |pmid=20007369 |pmc=2799887 |title=Giant Marseillevirus highlights the role of amoebae as a melting pot in emergence of chimeric microorganisms |journal=Proceedings of the National Academy of Sciences |volume=106 |issue=51 |pages=21848–53 |year=2009 |last1=Boyer |first1=M |last2=Yutin |first2=N |last3=Pagnier |first3=I |last4=Barrassi |first4=L |last5=Fournous |first5=G |last6=Espinosa |first6=L |last7=Robert |first7=C |last8=Azza |first8=S |last9=Sun |first9=S |last10=Rossmann |first10=M. G |last11=Suzan-Monti |first11=M |last12=La Scola |first12=B |last13=Koonin |first13=E. V |last14=Raoult |first14=D |bibcode=2009PNAS..10621848B }}</ref> Other members described around then (2007) and since then have been documented.<ref name=pmid25104553>{{cite journal |doi=10.1016/j.virol.2014.07.014 |pmid=25104553 |title=The expanding family Marseilleviridae |journal=Virology |volume=466-467 |pages=27–37 |year=2014 |last1=Aherfi |first1=Sarah |last2=La Scola |first2=Bernard |last3=Pagnier |first3=Isabelle |last4=Raoult |first4=Didier |last5=Colson |first5=Philippe }}</ref>
name=pmid27284144>{{cite journal |doi=10.1128/genomeA.00429-16 |pmid=27284144 |pmc=4901213 |title=Draft Genome Sequence of ''Tokyovirus'', a Member of the Family ''Marseilleviridae'' Isolated from the Arakawa River of Tokyo, Japan |journal=Genome Announcements |volume=4 |issue=3 |pages=e00429–16 |year=2016 |last1=Takemura |first1=Masaharu }}</ref>, das [[Kurlavirus]]<ref
name=pmid28685284>{{cite journal |doi=10.1007/s00705-017-3469-z |pmid=28685284 |title=Complete genome sequence of Kurlavirus, a novel member of the family Marseilleviridae isolated in Mumbai, India |journal=Archives of Virology |volume=162 |issue=10 |pages=3243 |year=2017 |last1=Chatterjee |first1=Anirvan |last2=Kondabagil |first2=Kiran }}</ref>, das [[Port-Miou-Virus]]<ref
name=Aherfi2015>Sarah Aherfi, Bernard La Scola, Isabelle Pagnier, Didier Raoult, Philippe Colson: ''The expanding family Marseilleviridae''. Genome Announc. 2015 Nov-Dec; 3(6): e01148-15. Online veröffentlicht am 25. November 2015, {{DOI|10.1128/genomeA.01148-15}}</ref> und das [[Nouemavirus]]<ref
name=Fabre2017>Elisabeth Fabre, Sandra Jeudy, Sébastien Santini, Matthieu Legendre, Mathieu Trauchessec, Yohann Couté, Jean-Michel Claverie, Chantal Abergel: Noumeavirus replication relies on a transient remote control of its host nucleus. In: Nature Communications. 8, Article number: 15087 (2017), {{DOI|10.1038/ncomms15087}}</ref> vorgeschlagen.


==References==
== Genom ==
Eine [[Promotor (Genetik)|Promotorsequenz]] - AAATATTT - wurde in Verbindung mit 55% der in diesem Virus identifizierten Gene gefunden. Die meisten dieser Sequenzen kommen in mehreren Kopien vor.<ref name=pmid28794030>{{cite journal |doi=10.1128/JVI.01088-17 |pmid=28794030 |pmc=5640848 |title=The Investigation of Promoter Sequences of Marseilleviruses Highlights a Remarkable Abundance of the AAATATTT Motif in Intergenic Regions |journal=Journal of Virology |volume=91 |issue=21 |pages=e01088–17 |year=2017 |last1=Oliveira |first1=Graziele Pereira |last2=Lima |first2=Maurício Teixeira |last3=Arantes |first3=Thalita Souza |last4=Assis |first4=Felipe Lopes |last5=Rodrigues |first5=Rodrigo Araújo Lima |last6=Da Fonseca |first6=Flávio Guimarães |last7=Bonjardim |first7=Cláudio Antônio |last8=Kroon |first8=Erna Geessien |last9=Colson |first9=Philippe |last10=La Scola |first10=Bernard |last11=Abrahão |first11=Jônatas Santos }}</ref>
{{Reflist|2}}


== Einzelnachweise ==
==External links==
<references />
* [http://viralzone.expasy.org/all_by_species/4740.html '''Viralzone''': Marseilleviridae]
* [http://ictvonline.org/virusTaxonomy.asp '''ICTV''']
{{Baltimore classification}}


[[Kategorie:Virusfamilie]]
{{Taxonbar|from=Q6773274}}


[[Category:Marseilleviridae| ]]
[[en:Marseilleviridae]]
[[es:Marseilleviridae]]
[[Category:Nucleocytoplasmic large DNA viruses]]
[[fr:Marseilleviridae]]
[[Category:Virus families]]

Version vom 25. November 2018, 22:22 Uhr

Marseilleviridae
Systematik
Klassifikation: Viren
Ordnung: 'Megavirales'
Familie: Marseilleviridae
Gattung: Marseillevirus
Taxonomische Merkmale
Genom: dsDNA zirkulär
Baltimore: Gruppe 1
Symmetrie: komplex
Hülle: vorhanden
Wissenschaftlicher Name
Marseillevirus

Die Marseilleviridae sind eine Virusfamilie, die 2012 erstmals beschrieben wurde.[1] Das Genom dieser Viren ist eine doppelsträngige DNA. Die Wirte sind oft Amöben, aber es gibt Hinweise darauf, dass sie auch beim Menschen gefunden werden.[2][3][4][5] Die Typusart wurde ursprünglich zum Mimivirus gruppiert Mimiviridae, spätere Studien zeigten jedoch, dass nur eine entfernte Verwandtschaft besteht. Mit Stand 2016 erkannte das Internationale Komitee für Taxonomie von Viren (ICTV) vier Spezies in dieser Familie an, die auf zwei Gattungen aufgeteilt sind.[6][7] Die Marseilleviridae gehören zu den Nucleocytoplasmic large DNA viruses (NCLDV), für die vorgeschlagen wurde, sie als Megavirales in den Rang einer Virusordnung zu erheben.

Spezies

Das erste bekannte Mitglied dieser Familie wurde als Acanthamoeba polyphaga marseillevirus (Marseillevirus) bezeichnet. Ein zweites Mitglied ist Acanthamoeba castellanii lausannevirus (Lausannevirus). Ein anderes Mitglied dieser Familie wurde bei Blutspendern isoliert: Giant Blood Marseillevirus (GBM).[4] Auch über ein Isolat von Insekten - das Insektomimevirus - wurde berichtet.[8]

Nach aktuellem Stand scheinen die Mitglieder in dieser Familie in mindestens 3 Gruppen zu fallen:

  1. Marseillevirus und Cannes8virus
  2. Insectomimevirus und Tunisvirus
  3. Lausannevirus

Ein sechstes potenzielles Mitglied dieser Familie - Melbournevirus - scheint mit der Marseillevirus/Cannes8virus-Klade verwandt zu sein.[9]

Ein siebtes Virus - das Brasilianische Marseillevirus - scheint zu einer vierten Viruslinie in dieser Familie zu gehören.[10]

Als weitere Mitglieder dieser Familie wurden das Tokyovirus[11], das Kurlavirus[12], das Port-Miou-Virus[13] und das Nouemavirus[14] vorgeschlagen.

Genom

Eine Promotorsequenz - AAATATTT - wurde in Verbindung mit 55% der in diesem Virus identifizierten Gene gefunden. Die meisten dieser Sequenzen kommen in mehreren Kopien vor.[15]

Einzelnachweise

  1. ↑ Philippe Colson, Isabelle Pagnier, Niyaz Yoosuf, Ghislain Fournous, Bernard La Scola, Didier Raoult: 'Marseilleviridae', a new family of giant viruses infecting amoebae. In: Archives of Virology. 158. Jahrgang, Nr. 4, 2012, S. 915–20, doi:10.1007/s00705-012-1537-y, PMID 23188494.
  2. ↑ Bernard La Scola: Looking at protists as a source of pathogenic viruses. In: Microbial Pathogenesis. 77. Jahrgang, 2014, S. 131–5, doi:10.1016/j.micpath.2014.09.005, PMID 25218687.
  3. ↑ Philippe Colson, Laura Fancello, Gregory Gimenez, Fabrice Armougom, Christelle Desnues, Ghislain Fournous, Niyaz Yoosuf, Matthieu Million, Bernard La Scola, Didier Raoult: Evidence of the megavirome in humans. In: Journal of Clinical Virology. 57. Jahrgang, Nr. 3, 2013, S. 191–200, doi:10.1016/j.jcv.2013.03.018, PMID 23664726.
  4. ↑ a b Nikolay Popgeorgiev, Mickaël Boyer, Laura Fancello, Sonia Monteil, Catherine Robert, Romain Rivet, Claude Nappez, Said Azza, Jacques Chiaroni, Didier Raoult, Christelle Desnues: Marseillevirus-Like Virus Recovered from Blood Donated by Asymptomatic Humans. In: The Journal of Infectious Diseases. 208. Jahrgang, Nr. 7, 2013, S. 1042–50, doi:10.1093/infdis/jit292, PMID 23821720.
  5. ↑ Sarah Aherfi, Philippe Colson, Gilles Audoly, Claude Nappez, Luc Xerri, Audrey Valensi, Matthieu Million, Hubert Lepidi, Regis Costello, Didier Raoult: Marseillevirus in lymphoma: A giant in the lymph node. In: The Lancet Infectious Diseases. 16. Jahrgang, Nr. 10, 2016, S. e225–e234, doi:10.1016/S1473-3099(16)30051-2, PMID 27502174.
  6. ↑ Viral Zone. ExPASy, abgerufen am 25. November 2018.
  7. ↑ Virus Taxonomy: 2016 Release. ICTV, abgerufen am 25. November 2018.
  8. ↑ Mondher Boughalmi, Isabelle Pagnier, Sarah Aherfi, Philippe Colson, Didier Raoult, Bernard La Scola: First Isolation of a Marseillevirus in the Diptera Syrphidae Eristalis tenax. In: Intervirology. 56. Jahrgang, Nr. 6, 2013, S. 386–94, doi:10.1159/000354560, PMID 24157885.
  9. ↑ G Doutre, N Philippe, C Abergel, J.-M Claverie: Genome Analysis of the First Marseilleviridae Representative from Australia Indicates that Most of Its Genes Contribute to Virus Fitness. In: Journal of Virology. 88. Jahrgang, Nr. 24, 2014, S. 14340–9, doi:10.1128/JVI.02414-14, PMID 25275139, PMC 4249118 (freier Volltext).
  10. ↑ Fábio Dornas, Felipe Assis, Sarah Aherfi, Thalita Arantes, Jônatas Abrahão, Philippe Colson, Bernard La Scola: A Brazilian Marseillevirus is the Founding Member of a Lineage in Family Marseilleviridae. In: Viruses. 8. Jahrgang, Nr. 3, 2016, S. 76, doi:10.3390/v8030076, PMID 26978387, PMC 4810266 (freier Volltext).
  11. ↑ Masaharu Takemura: Draft Genome Sequence of Tokyovirus, a Member of the Family Marseilleviridae Isolated from the Arakawa River of Tokyo, Japan. In: Genome Announcements. 4. Jahrgang, Nr. 3, 2016, S. e00429–16, doi:10.1128/genomeA.00429-16, PMID 27284144, PMC 4901213 (freier Volltext).
  12. ↑ Anirvan Chatterjee, Kiran Kondabagil: Complete genome sequence of Kurlavirus, a novel member of the family Marseilleviridae isolated in Mumbai, India. In: Archives of Virology. 162. Jahrgang, Nr. 10, 2017, S. 3243, doi:10.1007/s00705-017-3469-z, PMID 28685284.
  13. ↑ Sarah Aherfi, Bernard La Scola, Isabelle Pagnier, Didier Raoult, Philippe Colson: The expanding family Marseilleviridae. Genome Announc. 2015 Nov-Dec; 3(6): e01148-15. Online veröffentlicht am 25. November 2015, doi:10.1128/genomeA.01148-15
  14. ↑ Elisabeth Fabre, Sandra Jeudy, Sébastien Santini, Matthieu Legendre, Mathieu Trauchessec, Yohann Couté, Jean-Michel Claverie, Chantal Abergel: Noumeavirus replication relies on a transient remote control of its host nucleus. In: Nature Communications. 8, Article number: 15087 (2017), doi:10.1038/ncomms15087
  15. ↑ Graziele Pereira Oliveira, Maurício Teixeira Lima, Thalita Souza Arantes, Felipe Lopes Assis, Rodrigo Araújo Lima Rodrigues, Flávio Guimarães Da Fonseca, Cláudio Antônio Bonjardim, Erna Geessien Kroon, Philippe Colson, Bernard La Scola, Jônatas Santos Abrahão: The Investigation of Promoter Sequences of Marseilleviruses Highlights a Remarkable Abundance of the AAATATTT Motif in Intergenic Regions. In: Journal of Virology. 91. Jahrgang, Nr. 21, 2017, S. e01088–17, doi:10.1128/JVI.01088-17, PMID 28794030, PMC 5640848 (freier Volltext).
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