„Eugene Koonin“ – Versionsunterschied

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[[Datei:Eugene Koonin.jpg|mini|Eugene Koonin]]
{{Redirect|Koonin|the American theoretical physicist|Steven E. Koonin}}
{{Infobox scientist
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| birth_name = Eugene V. Koonin
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| birth_date = {{Birth date and age|1956|10|26}}
| birth_date = {{Birth date and age|1956|10|26}}
| birth_place = Moscow
| birth_place = Moscow
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| thesis_year = 1983
| thesis_year = 1983
| doctoral_advisor = [[Vadim I. Agol]]
| doctoral_advisor = [[Vadim I. Agol]]
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| website = {{URL|https://www.ncbi.nlm.nih.gov/CBBresearch/Koonin/}}
| website = {{URL|https://www.ncbi.nlm.nih.gov/CBBresearch/Koonin/}}
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| spouse =

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'''Eugene Viktorovich Koonin''' (Russian: Евге́ний Ви́кторович Ку́нин; born October 26, 1956) is a Russian-American biologist and Senior Investigator at the [[National Center for Biotechnology Information]] (NCBI). He is a recognised expert in the field of [[evolutionary biology|evolutionary]] and [[computational biology]].<ref>https://www.ncbi.nlm.nih.gov/CBBresearch/Koonin/ Koonin's page at the National Center for Biotechnology Information</ref><ref>{{cite book|author=Eugene V. Koonin|title=The Logic of Chance: The Nature and Origin of Biological Evolution|url=https://books.google.com/books?id=fvmv2kU6PrYC&pg=PA|access-date=5 April 2013|date=23 June 2011|publisher=FT Press|isbn=978-0-13-262317-9}}</ref><ref>{{Cite journal
'''Eugene Viktorovich Koonin''' ({{ruS|Евге́ний Ви́кторович Ку́нин}}), geboren am 26. Oktober 1956 in [[Moskau]] ist ein russisch-amerikanischer Biologe und Senior-Forscher ({{enS|senior investigator}} am {{lang|en|[[National Center for Biotechnology Information]]}} (NCBI). Er ist ein anerkannter Experte auf dem Gebiet der Evolutions- und Bioinformatik (en. {{lang|en|''computational biology''}}, „Computerbiologie“).<ref name="NCBI_Koonin"/><ref name="Koonin2013-04-05"/><ref name="Koonin2004_14986627"/>

== Ausbildung ==
Eugene Koonin erwarb 1978 einen [[Master of Science]] und 1983 einen Doktortitel (PhD) in [[Molekularbiologie]], beide an der Fakultät für Biologie der [[Staatliche Universität Moskau|Staatlichen Universität Moskau]]; seine Doktorarbeit mit dem Titel „Multienzymorganisation der Replikationskomplexe des Encephalomyocarditis-Virus“ ({{lang|en|Multienzyme organization of encephalomyocarditis virus replication complexes}}) wurde von Virologen und [[Genetik]]er Vadim I. Agol betreut.<ref name="cv"/>

== Forschungsarneit ==
Von 1985 bis 1991 arbeitete Eugene Koonin als Forschungswissenschaftler im Bereich der [[Bioinformatik]]/Computerbiologie an den Instituten für [[Poliomyelitis]] und [[Mikrobiologie]] der Akademie der Medizinischen Wissenschaften der [[UdSSR]] und untersuchte die Biochemie von [[Viren]] und die Genetik von Bakterien. 1991 wechselte Koonin zum NCBI, wo er seit 1996 eine Position als ''{{lang|en|Senior [[Investigation|Investigator]]'' innehat und Leiter der {{lang|en|Evolutionary Genomics Research Group}} ist.<ref name=cv />

Zu Koonins Hauptforschungszielen gehören die vergleichende Analyse [[DNA-Sequenzierung|sequenzierter]] [[Genom]]e und automatische Methoden zur Identifizierung von Genfunktionen auf Genomebene,<ref name="Lander2001"/>
sowie die Anwendung der vergleichenden Genomik für [[Phylogenetik|phylogenetische Analysen]], die (theoretische) Rekonstruktion früherer Lebensformen und die Erstellung groß angelegter evolutionärer Szenarien sowie die mathematische Modellierung der Genomevolution.<ref name="Koonin2011"/><ref name="Koonin2007_17708768"/><ref name="Koonin_2006_16984643"/>
Seine Forschungsarbeiten befassen sich auch mit der computergestützten Untersuchung der wichtigsten Schritte und Phasen in der Evolution des Lebens (z.&nbsp;B. die [[Eukaryoten#Entstehungsgeschichte|Eukaryogenese]], d.&nbsp;h. die Entstehung der [[Eukaryoten]]) und der Evolution der eukaryotischen Signalwege und Abstammungslinien aus der Perspektive der vergleichenden Genomik.<ref name="Uhlmann2000"/>

== Karriere ==
Eugene Koonin war als Lehrbeauftragter am {{lang|en|[[Georgia Institute of Technology]]}}, an der [[Boston University]] und an der [[Universität Haifa]] tätig.<ref name="cv"/><ref name="haifa-faculty"/>

Seit 2014 ist er Mitglied des beratenden Redaktionsausschusses von ''[[Trends in Genetics]]''<ref name="tig"/> und Mitherausgeber der Open-Access-Zeitschrift ''Biology Direct''.<ref name="biology-direct"/>
Von 1999 bis 2001 war er Mitglied des Redaktionsausschusses des Journals ''Bioinformatics''.
Darüber hinaus ist er auch Mitglied des Beirats für Bioinformatik an der [[Faculty of 1000]].<ref name="f1000"/>

Im Jahr 2016 wurde er in die [[National Academy of Sciences]] gewählt,<ref name="nasonline"/><ref name="Gabrielsen2017"/>
im selben Jahr wurde Koonin vom KI-Programm ''Semantic Scholar'' in die Liste der zehn einflussreichsten biomedizinischen Forscher aufgenommen.<ref name="Chawla2017"/>

== Bibliographie (Auswahl) ==
* {{cite journal |author=Valerian V. Dolja, Mart Krupovic, Eugene V. Koonin |title=Deep Roots and Splendid Boughs of the Global Plant Virome |journal=Annual Review of Phytopathology |volume=58 |issue=1 |date=2020-08-25 |issn=0066-4286 |doi=10.1146/annurev-phyto-030320-041346 |pages=23–53 |pmid=32459570|url=https://hal-pasteur.archives-ouvertes.fr/pasteur-02861246/file/Dolja_ARP2020.pdf }} [[Pasteur Institute|HAL Id]]: [http://hal-pasteur.archives-ouvertes.fr/pasteur-02861246 02861246].
* {{cite journal |author=Valerian V. Dolja, Alexander V. Karasev, Eugene V. Koonin |title=Molecular Biology and Evolution of Closteroviruses: Sophisticated Build-up of Large RNA Genomes |journal=Annual Review of Phytopathology |volume=32 |issue=1 |date=1994-09 |issn=0066-4286 |doi=10.1146/annurev.py.32.090194.001401 |pages=261–285 }}
* {{cite journal |author=Kira S. Makarova, Yuri I. Wolf, Omer S. Alkhnbashi, Fabrizio Costa, Shiraz A. Shah, Sita J. Saunders, Rodolphe Barrangou, Stan J.&nbsp;J. Brouns, Emmanuelle Charpentier, Daniel H. Haft, Philippe Horvath, Sylvain Moineau, Francisco J.&nbsp;M. Mojica, Rebecca M. Terns, Michael P. Terns, Malcolm F. White, Alexander F. Yakunin, Roger A. Garrett, John van der Oost, Rolf Backofen, Eugene V. Koonin |title=An updated evolutionary classification of CRISPR–Cas systems | journal=[[Nature Reviews Microbiology]] |volume=13 |issue=11 |date=2015-09-28 |issn=1740-1526 |doi=10.1038/nrmicro3569 |pages=722–736 |pmid=26411297 |pmc=5426118 }}
* {{cite journal |author=Toni Gabaldón, Eugene V. Koonin |title=Functional and evolutionary implications of gene orthology |journal=Nature Reviews Genetics |volume=14 |issue=5 |date=2013-04-04 |issn=1471-0056 |doi=10.1038/nrg3456 |pages=360–366|pmid=23552219 |pmc=5877793 }}

== Weblinks ==
* [https://scholia.toolforge.org/author/Q3699974 Eugene Koonin (Q3699974)], SCH<u>O</u>LIA

== Einzelnachweise ==
<references responsive>

<ref name="biology-direct">{{cite web|title=Biology Direct – Editorial Board|url=http://www.biologydirect.com/about/edboard|website=biologydirect.com}}</ref>

<ref name="cv">{{cite web|title=CV E. Koonin| url=https://web.archive.org/web/20190729181259/https://evolution.haifa.ac.il/index.php/27-people/cv/160-cv-e-koonin-sp-24914| website=Haifa Institute of Evolution}} Memento im Webarchiv vom 29. Juli 2019.</ref>

<ref name="f1000">{{cite web|title=Eugene Koonin: Advisory Board Member in Bioinformatics – F1000Prime|url=http://f1000.com/prime/thefaculty/member/1460257010243214|website=f1000.com|access-date=3 September 2014}}</ref>

<ref name="haifa-faculty">{{cite web|title=Faculty and Researchers| url=https://web.archive.org/web/20190801005529/http://evolution.haifa.ac.il:80/index.php/people/faculty-a-researchers |website=Haifa Institute of Evolution }} Memento im Webarchiv vom 1. August 2019.</ref>

<ref name="nasonline">{{cite web |url=http://www.nasonline.org/news-and-multimedia/news/may-3-2016-NAS-Election.html |title=National Academy of Sciences Members and Foreign Associates Elected|department=News from the National Academy of Sciences |publisher=[[National Academy of Sciences]] |date=2016-05-03 |archive-url=https://web.archive.org/web/20160506052951/http://www.nasonline.org/news-and-multimedia/news/may-3-2016-NAS-Election.html |archive-date=2016-05-06 |url-status=dead }}</ref>

<ref name="tig">{{cite web |title=Trends in Genetics: Advisory board |url=https://www.cell.com/trends/genetics/advisory-board |website= [[Cell (Zeitschrift)|cell.com]] }}, früher [https://web.archive.org/web/20160506182231/http://www.cell.com/trends/genetics/masthead Trends in Genetics: Masthead] (Memento im Webarchiv vom 6. Mai 2016).</ref>

<ref name="NCBI_Koonin">[https://www.ncbi.nlm.nih.gov/CBBresearch/Koonin/ Evolutionary Genomics Research Group — Eugene V. Koonin].</ref>

<ref name="Chawla2017">{{Cite web|last1=Chawla|first1=Dalmeet Singh|date=2017-10-17 |title=Who's the most influential biomedical scientist? Computer program guided by artificial intelligence says it knows|url=https://www.sciencemag.org/news/2017/10/who-s-most-influential-biomedical-scientist-computer-program-guided-artificial|access-date=2022-02-16|website=Science {{!}} AAAS|language=en}}</ref>

<ref name="Gabrielsen2017">{{Cite journal |last=Gabrielsen|first=Paul |date=2017-01-31 |title=Profile of Eugene V. Koonin |journal=[[Proceedings of the National Academy of Sciences of the United States of America]] |url=https://www.pnas.org/content/114/5/793 |volume=114 |issue=5 |pages=793–796 |doi=10.1073/pnas.1621406114 |issn=0027-8424 |pmid=28115717 |pmc=5293061 }}</ref>

<ref name="Koonin2004_14986627">{{Cite journal
| pmid = 14986627
| pmid = 14986627
| year = 2004
| year = 2004
| last1 = Koonin
| last1 = Koonin
| first1 = E. V.
| first1 = Eugene V.
| title = Eugene V. Koonin
| title = Q & A
| url=https://www.cell.com/action/showPdf?pii=S0960-9822%2804%2900025-9
| journal = Current Biology
| journal = Current Biology
| volume = 14
| volume = 14
| issue = 3
| issue = 3
| pages = R96–97
| pages = R96–R97
| doi=10.1016/j.cub.2004.01.010
| doi=10.1016/j.cub.2004.01.010
| doi-access = free
}}</ref>
}}</ref>


<ref name="Koonin_2006_16984643">{{Cite journal |author=Eugene V. Koonin, Tatiana G. Senkevich & Valerian V. Dolja |title=The ancient Virus World and evolution of cells |journal=Biology Direct |volume=1 |pages=29 |date=2006-09-19 |doi=10.1186/1745-6150-1-29 | pmid=16984643| pmc=1594570 }}</ref>
==Education==
Koonin gained a [[Master of Science]] in 1978 and a [[PhD]] in 1983 in [[molecular biology]], both from the Department of Biology at [[Moscow State University]]. His PhD thesis, titled "Multienzyme organization of encephalomyocarditis virus replication complexes", was supervised by [[Vadim I. Agol]].<ref name=cv>{{cite web|title=CV E. Koonin|url=http://evolution.haifa.ac.il/index.php/27-people/cv/160-cv-e-koonin-sp-24914|website=Haifa Institute of Evolution|access-date=28 July 2020}}</ref>


<ref name="Koonin2007_17708768">{{Cite journal |author=Eugene V. Koonin |doi=10.1186/1745-6150-2-21 |title=The Biological Big Bang model for the major transitions in evolution |url=https://biologydirect.biomedcentral.com/articles/10.1186/1745-6150-2-21 |journal=Biology Direct |volume=2 |pages=21 |date=2007-08-20 |pmid=17708768| pmc=1973067 }}</ref>
==Research==
From 1985 until 1991, Koonin worked as a research scientist in computational biology in the Institutes of [[Poliomyelitis]] and Microbiology at the [[USSR Academy of Medical Sciences]], studying virus biochemistry and bacterial genetics. In 1991, Koonin moved to the NCBI, where he has held a Senior Investigator position since 1996.<ref name=cv />


<ref name="Koonin2011">{{Cite journal |author=Eugene V. Koonin <!--| editor1-last = Bourne | editor1-first = Philip E.--> |title=Are There Laws of Genome Evolution? |url=https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002173 |doi= 10.1371/journal.pcbi.1002173 |journal=PLOS Computational Biology |volume= 7 | issue = 8 | pages = e1002173 | date = 2011-08-25 | pmid = 21901087| pmc = 3161903| arxiv = 1108.3589 | bibcode = 2011PLSCB...7E2173K }}</ref>
Koonin's principal research goals include the comparative analysis of sequenced genomes and automatic methods for genome-scale annotation of gene functions.<ref>{{Cite journal | first1 = E. S.| last1 = Lander| author-link1 = Eric Lander| last2 = Linton | first2 = M. | last3 = Birren | first3 = B. | last4 = Nusbaum | first4 = C. | last5 = Zody | first5 = C.| last6 = Baldwin | first6 = J. | last7 = Devon | first7 = K. | last8 = Dewar | first8 = K. | last9 = Doyle | first9 = M. | last10 = Fitzhugh | first10 = W. | last11 = Funke | first11 = R. | last12 = Gage | first12 = D. | last13 = Harris | first13 = K. | last14 = Heaford | first14 = A. | last15 = Howland | first15 = J. | last16 = Kann | first16 = L. | last17 = Lehoczky | first17 = J. | last18 = Levine | first18 = R. | last19 = McEwan | first19 = P. | last20 = McKernan | first20 = K. | last21 = Meldrim | first21 = J. | last22 = Mesirov | first22 = J. P. | last23 = Miranda | first23 = C. | last24 = Morris | first24 = W. | last25 = Naylor | first25 = J. | last26 = Raymond | first26 = C. | last27 = Rosetti | first27 = M. | last28 = Santos | first28 = R. | last29 = Sheridan | first29 = A. | last30 = Sougnez | first30 = C. | display-authors = 29| title = Initial sequencing and analysis of the human genome | journal = Nature | volume = 409 | issue = 6822 | pages = 860–921 | date =Feb 2001 | issn = 0028-0836 | pmid = 11237011 | doi = 10.1038/35057062| url = https://deepblue.lib.umich.edu/bitstream/2027.42/62798/1/409860a0.pdf | bibcode = 2001Natur.409..860L| doi-access = free }}</ref> He also researches in the application of comparative [[genomics]] for phylogenetic analysis, reconstruction of ancestral life forms and building large-scale evolutionary scenarios, as well as mathematical modeling of [[genome evolution]].<ref>{{Cite journal | last1 = Koonin | first1 = E. V. | author-link = Eugene Koonin| editor1-last = Bourne | editor1-first = Philip E. | title = Are There Laws of Genome Evolution? | doi = 10.1371/journal.pcbi.1002173 | journal = [[PLOS Computational Biology]] | volume = 7 | issue = 8 | pages = e1002173 | year = 2011 | pmid = 21901087| pmc = 3161903| arxiv = 1108.3589 | bibcode = 2011PLSCB...7E2173K }} {{open access}}</ref><ref>{{Cite journal | last1 = Koonin | first1 = E. V. | author-link = Eugene Koonin| doi = 10.1186/1745-6150-2-21 | title = The Biological Big Bang model for the major transitions in evolution | journal = Biology Direct | volume = 2 | pages = 21 | year = 2007 | pmid = 17708768| pmc =1973067 }}</ref><ref>{{Cite journal | last1 = Koonin | first1 = E. V. | author-link1 = Eugene Koonin| last2 = Senkevich | first2 = T. G. | last3 = Dolja | first3 = V. V. | title = The ancient Virus World and evolution of cells | journal = Biology Direct | volume = 1 | pages = 29 | year = 2006 | doi = 10.1186/1745-6150-1-29 | pmid = 16984643| pmc =1594570 }}</ref> Koonin's research also investigates computational study of the major transitions in the evolution of life (such as the origin of [[eukaryote]]s), the evolution of eukaryotic signaling and developmental pathways from the comparative-genomic perspective.<ref>{{Cite journal

<ref name="Koonin2013-04-05">{{cite book|author=Eugene V. Koonin|title=The Logic of Chance: The Nature and Origin of Biological Evolution|url=https://books.google.com/books?id=fvmv2kU6PrYC&pg=PA|access-date=5 April 2013|date=2011-06-23|publisher=FT Press|isbn=978-0-13-262317-9}}</ref>

<ref name="Lander2001">{{Cite journal | author=[[Eric Lander|Eric S. Lander]], Lauren M. Linton, Bruce Birren, Chad Nusbaum, Michael C. Zody, Jennifer Baldwin, Keri Devon, K. Dewar, M. Doyle, William FitzHugh, R. Funke, D. Gage, K. Harris, A. Heaford, J. Howland, L. Kann, J. Lehoczky, R. Levine, P. McEwan, K. McKernan, J. Meldrim, Jill P. Mesirov, C. Miranda, W. Morris, J. Naylor, C. Raymond, M. Rosetti, R. Santos, A. Sheridan, C. Sougnez ''et&nbsp;al.'' | title = Initial sequencing and analysis of the human genome | journal = Nature | volume = 409 | issue = 6822 | pages = 860–921 | date=2001-02 | issn = 0028-0836 | pmid = 11237011 | doi = 10.1038/35057062| url = https://deepblue.lib.umich.edu/bitstream/2027.42/62798/1/409860a0.pdf | bibcode = 2001Natur.409..860L }}</ref>

<ref name="Uhlmann2000">{{Cite journal
| pmid = 11081625
| pmid = 11081625
| year = 2000
| year = 2000
| author = Frank Uhlmann, Dominik Wernic, Marc-André Poupart, Eugene V. Koonin, [[Kim Nasmyth]]
| last1 = Uhlmann
| url=https://www.cell.com/cell/fulltext/S0092-8674(00)00130-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867400001306%3Fshowall%3Dtrue
| first1 = F | author-link1 = Frank Uhlmann
| title = Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast
| title = Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast
| journal = [[Cell (journal)|Cell]]
| journal = [[Cell (Zeitschrift)|Cell]]
| volume = 103
| volume = 103
| issue = 3
| issue = 3
| pages = 375–386
| pages = 375–386
| last2 = Wernic
| first2 = D
| last3 = Poupart
| first3 = M. A.
| last4 = Koonin
| first4 = E. V. | author-link4 = Eugene Koonin
| last5 = Nasmyth
| first5 = K | author-link5 = Kim Nasmyth
| doi=10.1016/s0092-8674(00)00130-6
| doi=10.1016/s0092-8674(00)00130-6
| s2cid = 2667617
| doi-access = free
}}</ref>
}}</ref>


</references>
==Career==
Koonin has worked as Adjunct Professor at the [[Georgia Institute of Technology]], [[Boston University]] and the [[University of Haifa]].<ref name=cv /><ref name=haifa-faculty>{{cite web|title=Faculty and Researchers|url=http://evolution.haifa.ac.il/index.php/people/faculty-a-researchers|website=Haifa Institute of Evolution|access-date=28 July 2020}}</ref>


{{SORTIERUNG:Koonin, Eugene}}
As of 2014, Koonin serves on the advisory editorial board of ''[[Trends in Genetics]]'',<ref name=tig>{{cite web|title=Masthead: Trends in Genetics|url=http://www.cell.com/trends/genetics/masthead|website=cell.com|access-date=3 September 2014}}</ref> and is co-Editor-in-Chief of the open access journal ''[[Biology Direct]]''.<ref name=biology-direct>{{cite web|title=Biology Direct – Editorial Board|url=http://www.biologydirect.com/about/edboard|website=biologydirect.com|access-date=3 September 2014}}</ref> He served on the editorial board of ''[[Bioinformatics (journal)|Bioinformatics]]'' from 1999 until 2001. Koonin is also an advisory board member in bioinformatics at [[Faculty of 1000]].<ref name=f1000>{{cite web|title=Eugene Koonin: Advisory Board Member in Bioinformatics – F1000Prime|url=http://f1000.com/prime/thefaculty/member/1460257010243214|website=f1000.com|access-date=3 September 2014}}</ref>


[[Kategorie:Bioinformatiker]]
In 2016 he was elected to the [[National Academy of Sciences]].<ref>{{citation|url=http://www.nasonline.org/news-and-multimedia/news/may-3-2016-NAS-Election.html|title=National Academy of Sciences Members and Foreign Associates Elected|department=News from the National Academy of Sciences|publisher=[[National Academy of Sciences]]|date=May 3, 2016|access-date=2016-05-14|archive-url=https://web.archive.org/web/20160506052951/http://www.nasonline.org/news-and-multimedia/news/may-3-2016-NAS-Election.html|archive-date=May 6, 2016|url-status=dead}}.</ref><ref>{{Cite journal|last=Gabrielsen|first=Paul|date=2017-01-31|title=Profile of Eugene V. Koonin|journal=[[Proceedings of the National Academy of Sciences of the United States of America]]|volume=114|issue=5|pages=793–796|doi=10.1073/pnas.1621406114|issn=0027-8424|pmid=28115717|pmc=5293061|doi-access=free}}</ref>
[[Kategorie:Virologe]]
[[Kategorie:Bioinformatiker]]
[[Kategorie:Evolutionsbiologe]]
[[Kategorie:Theoretischer Biologe]]
[[Kategorie:Geboren 1956]]
[[Kategorie:Mann]]-->


{{Personendaten
In 2016, [[Semantic Scholar]] AI program included Koonin on its list of top ten most influential biomedical researchers.<ref>{{Cite web|last1=Chawla|first1=Dalmeet Singh|date=17 October 2017 |title=Who's the most influential biomedical scientist? Computer program guided by artificial intelligence says it knows|url=https://www.sciencemag.org/news/2017/10/who-s-most-influential-biomedical-scientist-computer-program-guided-artificial|access-date=2022-02-16|website=Science {{!}} AAAS|language=en}}</ref>
|NAME=Koonin, Eugene Viktorovich

|ALTERNATIVNAMEN=Евге́ний Ви́кторович Ку́нин
==References==
|KURZBESCHREIBUNG=russischstämmiger amerikanischer Bioinformatiker
{{reflist}}
|GEBURTSDATUM=26. Oktober 1956

|GEBURTSORT=[[Moskau]]
==Selected bibliography==
|STERBEDATUM=
* {{cite journal | last1=Dolja | first1=Valerian V. | last2=Krupovic | first2=Mart | last3=Koonin | first3=Eugene V. | author3-link=Eugene Koonin | title=Deep Roots and Splendid Boughs of the Global Plant Virome | journal=[[Annual Review of Phytopathology]] | publisher=[[Annual Reviews (publisher)|Annual Reviews]] | volume=58 | issue=1 | date=2020-08-25 | issn=0066-4286 | doi=10.1146/annurev-phyto-030320-041346 | pages=23–53 | s2cid=218974980 | pmid=32459570| url=https://hal-pasteur.archives-ouvertes.fr/pasteur-02861246/file/Dolja_ARP2020.pdf }} [[Pasteur Institute|HAL Id]]: [http://hal-pasteur.archives-ouvertes.fr/pasteur-02861246 02861246].
|STERBEORT=
* {{cite journal | last1=Dolja | first1=Valerian V. | last2=Karasev | first2=Alexander V. | last3=Koonin | first3=Eugene V. | title=Molecular Biology and Evolution of Closteroviruses: Sophisticated Build-up of Large RNA Genomes | journal=[[Annual Review of Phytopathology]] | publisher=[[Annual Reviews (publisher)|Annual Reviews]] | volume=32 | issue=1 | year=1994 | issn=0066-4286 | doi=10.1146/annurev.py.32.090194.001401 | pages=261–285}}
}}
* {{cite journal | last1=Makarova | first1=Kira S. | last2=Wolf | first2=Yuri I. | last3=Alkhnbashi | first3=Omer S. | last4=Costa | first4=Fabrizio | last5=Shah | first5=Shiraz A. | last6=Saunders | first6=Sita J. | last7=Barrangou | first7=Rodolphe | last8=Brouns | first8=Stan J. J. | last9=Charpentier | first9=Emmanuelle | author9-link=Emmanuelle Charpentier | last10=Haft | first10=Daniel H. | last11=Horvath | first11=Philippe | last12=Moineau | first12=Sylvain | last13=Mojica | first13=Francisco J. M. | last14=Terns | first14=Rebecca M. | last15=Terns | first15=Michael P. | last16=White | first16=Malcolm F. | last17=Yakunin | first17=Alexander F. | last18=Garrett | first18=Roger A. | last19=van der Oost | first19=John | last20=Backofen | first20=Rolf | last21=Koonin | first21=Eugene V. | author21-link=Eugene Koonin | title=An updated evolutionary classification of CRISPR–Cas systems | journal=[[Nature Reviews Microbiology]] | publisher=[[Nature Portfolio]] | volume=13 | issue=11 | date=2015-09-28 | issn=1740-1526 | doi=10.1038/nrmicro3569 | pages=722–736 | pmid=26411297 | pmc=5426118}}
* {{cite journal | last1=Gabaldón | first1=Toni | last2=Koonin | first2=Eugene V. | author2-link=Eugene Koonin | title=Functional and evolutionary implications of gene orthology | journal=[[Nature Reviews Genetics]] | publisher=[[Nature Portfolio]] | volume=14 | issue=5 | date=2013-04-04 | issn=1471-0056 | doi=10.1038/nrg3456 | pages=360–366| pmid=23552219 | pmc=5877793 }}

==External links==
*{{Scholia-inline|Q3699974|author}}

{{Authority control}}

{{DEFAULTSORT:Koonin, Eugene}}
[[Category:1956 births]]
[[Category:Living people]]
[[Category:Theoretical biologists]]
[[Category:Russian bioinformaticians]]
[[Category:Extended evolutionary synthesis]]
[[Category:Human Genome Project scientists]]
[[Category:Members of the United States National Academy of Sciences]]
[[Category:Foreign Members of the Russian Academy of Sciences]]
[[Category:21st-century American biologists]]
[[Category:Moscow State University alumni]]

Version vom 18. Februar 2022, 10:36 Uhr

Eugene Koonin

Eugene Viktorovich Koonin (russisch Евге́ний Ви́кторович Ку́нин), geboren am 26. Oktober 1956 in Moskau ist ein russisch-amerikanischer Biologe und Senior-Forscher (englisch senior investigator am National Center for Biotechnology Information (NCBI). Er ist ein anerkannter Experte auf dem Gebiet der Evolutions- und Bioinformatik (en. computational biology, „Computerbiologie“).[1][2][3]

Ausbildung

Eugene Koonin erwarb 1978 einen Master of Science und 1983 einen Doktortitel (PhD) in Molekularbiologie, beide an der Fakultät für Biologie der Staatlichen Universität Moskau; seine Doktorarbeit mit dem Titel „Multienzymorganisation der Replikationskomplexe des Encephalomyocarditis-Virus“ (Multienzyme organization of encephalomyocarditis virus replication complexes) wurde von Virologen und Genetiker Vadim I. Agol betreut.[4]

Forschungsarneit

Von 1985 bis 1991 arbeitete Eugene Koonin als Forschungswissenschaftler im Bereich der Bioinformatik/Computerbiologie an den Instituten für Poliomyelitis und Mikrobiologie der Akademie der Medizinischen Wissenschaften der UdSSR und untersuchte die Biochemie von Viren und die Genetik von Bakterien. 1991 wechselte Koonin zum NCBI, wo er seit 1996 eine Position als {{lang|en|Senior Investigator innehat und Leiter der Evolutionary Genomics Research Group ist.[4]

Zu Koonins Hauptforschungszielen gehören die vergleichende Analyse sequenzierter Genome und automatische Methoden zur Identifizierung von Genfunktionen auf Genomebene,[5] sowie die Anwendung der vergleichenden Genomik für phylogenetische Analysen, die (theoretische) Rekonstruktion früherer Lebensformen und die Erstellung groß angelegter evolutionärer Szenarien sowie die mathematische Modellierung der Genomevolution.[6][7][8] Seine Forschungsarbeiten befassen sich auch mit der computergestützten Untersuchung der wichtigsten Schritte und Phasen in der Evolution des Lebens (z. B. die Eukaryogenese, d. h. die Entstehung der Eukaryoten) und der Evolution der eukaryotischen Signalwege und Abstammungslinien aus der Perspektive der vergleichenden Genomik.[9]

Karriere

Eugene Koonin war als Lehrbeauftragter am Georgia Institute of Technology, an der Boston University und an der Universität Haifa tätig.[4][10]

Seit 2014 ist er Mitglied des beratenden Redaktionsausschusses von Trends in Genetics[11] und Mitherausgeber der Open-Access-Zeitschrift Biology Direct.[12] Von 1999 bis 2001 war er Mitglied des Redaktionsausschusses des Journals Bioinformatics. Darüber hinaus ist er auch Mitglied des Beirats für Bioinformatik an der Faculty of 1000.[13]

Im Jahr 2016 wurde er in die National Academy of Sciences gewählt,[14][15] im selben Jahr wurde Koonin vom KI-Programm Semantic Scholar in die Liste der zehn einflussreichsten biomedizinischen Forscher aufgenommen.[16]

Bibliographie (Auswahl)

  • Valerian V. Dolja, Mart Krupovic, Eugene V. Koonin: Deep Roots and Splendid Boughs of the Global Plant Virome. In: Annual Review of Phytopathology. 58. Jahrgang, Nr. 1, 25. August 2020, ISSN 0066-4286, S. 23–53, doi:10.1146/annurev-phyto-030320-041346, PMID 32459570 (archives-ouvertes.fr [PDF]). HAL Id: 02861246.
  • Valerian V. Dolja, Alexander V. Karasev, Eugene V. Koonin: Molecular Biology and Evolution of Closteroviruses: Sophisticated Build-up of Large RNA Genomes. In: Annual Review of Phytopathology. 32. Jahrgang, Nr. 1, September 1994, ISSN 0066-4286, S. 261–285, doi:10.1146/annurev.py.32.090194.001401.
  • Kira S. Makarova, Yuri I. Wolf, Omer S. Alkhnbashi, Fabrizio Costa, Shiraz A. Shah, Sita J. Saunders, Rodolphe Barrangou, Stan J. J. Brouns, Emmanuelle Charpentier, Daniel H. Haft, Philippe Horvath, Sylvain Moineau, Francisco J. M. Mojica, Rebecca M. Terns, Michael P. Terns, Malcolm F. White, Alexander F. Yakunin, Roger A. Garrett, John van der Oost, Rolf Backofen, Eugene V. Koonin: An updated evolutionary classification of CRISPR–Cas systems. In: Nature Reviews Microbiology. 13. Jahrgang, Nr. 11, 28. September 2015, ISSN 1740-1526, S. 722–736, doi:10.1038/nrmicro3569, PMID 26411297, PMC 5426118 (freier Volltext).
  • Toni Gabaldón, Eugene V. Koonin: Functional and evolutionary implications of gene orthology. In: Nature Reviews Genetics. 14. Jahrgang, Nr. 5, 4. April 2013, ISSN 1471-0056, S. 360–366, doi:10.1038/nrg3456, PMID 23552219, PMC 5877793 (freier Volltext).

Weblinks

Einzelnachweise

  1. ↑ Evolutionary Genomics Research Group — Eugene V. Koonin.
  2. ↑ Eugene V. Koonin: The Logic of Chance: The Nature and Origin of Biological Evolution. FT Press, 2011, ISBN 978-0-13-262317-9 (google.com [abgerufen am 5. April 2013]).
  3. ↑ Eugene V. Koonin: Q & A. In: Current Biology. 14. Jahrgang, Nr. 3, 2004, S. R96–R97, doi:10.1016/j.cub.2004.01.010, PMID 14986627 (cell.com).
  4. ↑ a b c CV E. Koonin. In: Haifa Institute of Evolution. Fehler beim Aufruf der Vorlage:Cite web: Archiv im Parameter URL erkannt. Archive müssen im Parameter Archiv-URL angegeben werden. Memento im Webarchiv vom 29. Juli 2019.
  5. ↑ Eric S. Lander, Lauren M. Linton, Bruce Birren, Chad Nusbaum, Michael C. Zody, Jennifer Baldwin, Keri Devon, K. Dewar, M. Doyle, William FitzHugh, R. Funke, D. Gage, K. Harris, A. Heaford, J. Howland, L. Kann, J. Lehoczky, R. Levine, P. McEwan, K. McKernan, J. Meldrim, Jill P. Mesirov, C. Miranda, W. Morris, J. Naylor, C. Raymond, M. Rosetti, R. Santos, A. Sheridan, C. Sougnez et al.: Initial sequencing and analysis of the human genome. In: Nature. 409. Jahrgang, Nr. 6822, Februar 2001, ISSN 0028-0836, S. 860–921, doi:10.1038/35057062, PMID 11237011, bibcode:2001Natur.409..860L (umich.edu [PDF]).
  6. ↑ Eugene V. Koonin: Are There Laws of Genome Evolution? In: PLOS Computational Biology. 7. Jahrgang, Nr. 8, 25. August 2011, S. e1002173, doi:10.1371/journal.pcbi.1002173, PMID 21901087, PMC 3161903 (freier Volltext), arxiv:1108.3589, bibcode:2011PLSCB...7E2173K (plos.org).
  7. ↑ Eugene V. Koonin: The Biological Big Bang model for the major transitions in evolution. In: Biology Direct. 2. Jahrgang, 20. August 2007, S. 21, doi:10.1186/1745-6150-2-21, PMID 17708768, PMC 1973067 (freier Volltext) – (biomedcentral.com).
  8. ↑ Eugene V. Koonin, Tatiana G. Senkevich & Valerian V. Dolja: The ancient Virus World and evolution of cells. In: Biology Direct. 1. Jahrgang, 19. September 2006, S. 29, doi:10.1186/1745-6150-1-29, PMID 16984643, PMC 1594570 (freier Volltext).
  9. ↑ Frank Uhlmann, Dominik Wernic, Marc-André Poupart, Eugene V. Koonin, Kim Nasmyth: Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast. In: Cell. 103. Jahrgang, Nr. 3, 2000, S. 375–386, doi:10.1016/s0092-8674(00)00130-6, PMID 11081625 (cell.com).
  10. ↑ Faculty and Researchers. In: Haifa Institute of Evolution. Fehler beim Aufruf der Vorlage:Cite web: Archiv im Parameter URL erkannt. Archive müssen im Parameter Archiv-URL angegeben werden. Memento im Webarchiv vom 1. August 2019.
  11. ↑ Trends in Genetics: Advisory board. In: cell.com., früher Trends in Genetics: Masthead (Memento im Webarchiv vom 6. Mai 2016).
  12. ↑ Biology Direct – Editorial Board. In: biologydirect.com.
  13. ↑ Eugene Koonin: Advisory Board Member in Bioinformatics – F1000Prime. In: f1000.com. Abgerufen am 3. September 2014.
  14. ↑ National Academy of Sciences Members and Foreign Associates Elected. National Academy of Sciences, 3. Mai 2016, archiviert vom Original am 6. Mai 2016;.
  15. ↑ Paul Gabrielsen: Profile of Eugene V. Koonin. In: Proceedings of the National Academy of Sciences of the United States of America. 114. Jahrgang, Nr. 5, 31. Januar 2017, ISSN 0027-8424, S. 793–796, doi:10.1073/pnas.1621406114, PMID 28115717, PMC 5293061 (freier Volltext) – (pnas.org).
  16. ↑ Dalmeet Singh Chawla: Who's the most influential biomedical scientist? Computer program guided by artificial intelligence says it knows. In: Science | AAAS. 17. Oktober 2017, abgerufen am 16. Februar 2022 (englisch).

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Personendaten
NAME Koonin, Eugene Viktorovich
ALTERNATIVNAMEN Евге́ний Ви́кторович Ку́нин
KURZBESCHREIBUNG russischstämmiger amerikanischer Bioinformatiker
GEBURTSDATUM 26. Oktober 1956
GEBURTSORT Moskau
Abgerufen von „https://de.wikipedia.org/w/index.php?title=Eugene_Koonin&oldid=220324322“